The world-renowned cardiac surgeon Sir Magdi Yacoub from Imperial College and the Aswan Heart Center, focusing on the present and future of organ transplantation, highlighted the significant increase in noncommunicable diseases—admittedly in the pre-COVID-19 era—and the ever-relevant position of transplant, which, however, is now complemented by the use of mechanical circulatory support devices (left ventricular assist devices—LVADs), which are not merely a “bridge” to transplantation but also promote myocardial regeneration.
Specifically, he stated that «With their use, the likelihood of their removal and the heart’s return to normal function (recovery) reaches up to 40%, depending on the cause of heart failure and the treatment approaches of the various centers.”. Myocardial regeneration is always the goal».
He then mentioned the Kuhn's cycle in which conventional science is synergistically influenced by revolutionary discoveries. He emphasized the need for a comprehensive approach and the treatment of various pathological processes that lead to heart failure.
In addition, he pointed out that «»The heart exhibits a form of Alzheimer's disease due to pathological protein changes—'proteotoxicity.'". He added that it is important to establish indicators for monitoring the functioning of organs—biomarkers. He concluded by referring to the concept of interaction between various systems in the form of networks, access to big data (big data), and the contribution of artificial intelligence to the synthesis and utilization of this data.
